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Vaccinia Virus CD8+ T-Cell Dominance Hierarchies Cannot Be Altered by Prior Immunization with Individual Peptides

Wang, Yang; Flesch, Inge; Tscharke, David


Heterologous prime-boost is a common vaccination strategy to elicit CD8+ T cells (TCD8+), and vaccinia virus (VACV) has been widely used as a boosting vector. Studies with other viruses have suggested that priming may reduce responses to native epitopes in boosting vectors as well as improve responses to primed epitopes. We explored this possibility with a VACV model in mice and find that irrespective of an epitope's dominance, prior priming was able to double TCD8+ responses. More...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.00410-09


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