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Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation

Wu, Zuopeng; Yates (previously Loy), Adele; Hoyne, Gerard; Goodnow, Christopher


CD45 is the most abundant protein tyrosine phosphatase in the plasma membrane of T cells and serves a critical role in TCR signaling. Different CD45 isoforms are made by alternative mRNA splicing depending on the stage of T cell development and activation, yet their role remains unclear. Expression of CD45RA and RC isoforms is increased 20- to 200-fold on T cells from thunder mice with a loss-of-function mutation in the RNA-binding protein, heterogeneous nuclear ribonucleoprotein L-like...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.0903625


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