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Purine uptake in Plasmodium: transport versus metabolism

Kirk, Kiaran; Howitt, Susan; Broer, Stefan; Saliba, Kevin; Downie, Megan

Description

In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/51077
Source: Trends in Parasitology
DOI: 10.1016/j.pt.2009.03.006

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