Purine uptake in Plasmodium: transport versus metabolism
In a recent paper, Quashie et al. have proposed that purine uptake into the intraerythrocytic malaria parasite involves four different plasma membrane transporters - two high affinity and two low affinity. They equate one of the two high-affinity transporters with PfNT1, a transporter reported previously to be a low-affinity system. Here, we offer an alternative interpretation of their data, suggesting that the conclusions drawn by Quashie et al. take insufficient account of metabolism.
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|Source:||Trends in Parasitology|
|01_Kirk_Purine_uptake_in_Plasmodium:_2009.pdf||339.58 kB||Adobe PDF||Request a copy|
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