Differential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-Cell-Derived Alphaviruses
Shabman, Reed S; Morrison, Thomas E.; Moore, Christopher; White, Laura; Suthar, Mehul S; Hueston, Linda; Rulli, Nestor E.; Lidbury, Brett; Ting, Jenny P-Y; Mahalingam, Suresh (Surendran); Heise, Mark T
Dendritic cells (DCs) are an important early target cell for many mosquito-borne viruses, and in many cases mosquito-cell-derived arboviruses more efficiently infect DCs than viruses derived from mammalian cells. However, whether mosquito-cell-derived viruses differ from mammalian-cell-derived viruses in their ability to induce antiviral responses in the infected dendritic cell has not been evaluated. In this report, alphaviruses, which are mosquito-borne viruses that cause diseases ranging...[Show more]
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|Source:||Journal of Virology|
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