Differential Induction of Type I Interferon Responses in Myeloid Dendritic Cells by Mosquito and Mammalian-Cell-Derived Alphaviruses
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Shabman, Reed S.; Morrison, Thomas E.; Moore, Christopher; White, Laura; Suthar, Mehul S.; Hueston, Linda; Rulli, Nestor E.; Lidbury, Brett; Ting, Jenny P-Y; Mahalingam, Suresh (Surendran); Heise, Mark T
Description
Dendritic cells (DCs) are an important early target cell for many mosquito-borne viruses, and in many cases mosquito-cell-derived arboviruses more efficiently infect DCs than viruses derived from mammalian cells. However, whether mosquito-cell-derived viruses differ from mammalian-cell-derived viruses in their ability to induce antiviral responses in the infected dendritic cell has not been evaluated. In this report, alphaviruses, which are mosquito-borne viruses that cause diseases ranging...[Show more]
Collections | ANU Research Publications |
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Date published: | 2007 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/51020 |
Source: | Journal of Virology |
DOI: | 10.1128/JVI.01590-06 |
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01_Shabman_Differential_Induction_of_Type_2007.pdf | 571.86 kB | Adobe PDF | Request a copy |
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