Harmonin (Ush1c) is required in zebrafish Muller glial cells for photoreceptor synaptic development and function
Phillips, Jennifer B; Blanco-Sanchez, Bernardo; Lentz, Jennifer J; Tallafuss, Alexandra; Khanobdee, Kornnika; Sampath, Srirangan; Jacobs, Zachary G; Han, Philip F; Mishra, Monalisa; Titus, Tom A; Williams, David S; Keats, Bronya; Washbourne, Philip; Westerfield, Monte
Usher syndrome is the most prevalent cause of hereditary deaf-blindness, characterized by congenital sensorineural hearing impairment and progressive photoreceptor degeneration beginning in childhood or adolescence. Diagnosis and management of this disease are complex, and the molecular changes underlying sensory cell impairment remain poorly understood. Here we characterize two zebrafish models for a severe form of Usher syndrome, Usher syndrome type 1C (USH1C): one model is a mutant with a...[Show more]
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