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Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

Linterman, Michelle; Rigby, Robert; Wong, Raphael; Silva, Diego; Withers, David; Anderson, Graham; Verma, Naresh; Brink, Robert; Hutloff, Andreas; Goodnow, Christopher; Garcia De Vinuesa, Maria Carola

Description

During evolutionary adaptation in the immune system, host defense is traded off against autoreactivity. Signals through the costimulatory receptor CD28 enable T cells to respond specifically to pathogens, whereas those through the related costimulatory r

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/50983
Source: Immunity
DOI: 10.1016/j.immuni.2008.12.015

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