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Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus

Lidbury, Brett; Rulli, Nestor E.; Suhrbier, Andreas; Smith, Paul; McColl, Shaun; Cunningham, Anthony; Tarkowski, Andrej; van Rooijen, Nico; Fraser, Robert J; Mahalingam, Suresh (Surendran)


Alphaviruses, such as chikungunya virus and Ross River virus (RRV), are associated with outbreaks of infectious rheumatic disease in humans worldwide. Using an established mouse model of disease that mimics RRV disease in humans, we showed that macrophage-derived factors are critical in the development of striated muscle and joint tissue damage. Histologic analyses of muscle and ankle joint tissues demonstrated a substantial reduction in inflammatory infiltrates in infected mice depleted of...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Infectious Diseases
DOI: 10.1086/587841


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