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Early focal expression of the chemokine Ccl2 by Muller cells during exposure to damage-inducing bright continuous light

Rutar, Matthew; Natoli, Riccardo; Valter (Valter-Kocsi), Krisztina; Provis, Jan


PURPOSE. To investigate the time course and localization of Ccl2 expression and recruitment of inflammatory cells associated with light-induced photoreceptor degeneration. METHODS. Sprague-Dawley (SD) rats were exposed to 1000 lux light for up to 24 hours, after which some animals were allowed to recover in dim light (5 lux) for 3 or 7 days. During and after exposure to light, the animals were euthanatized and the retinas processed. Ccl2 expression was assessed by qPCR, immunohistochemistry,...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.10-6010
Access Rights: Open Access


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