Early focal expression of the chemokine Ccl2 by Muller cells during exposure to damage-inducing bright continuous light
PURPOSE. To investigate the time course and localization of Ccl2 expression and recruitment of inflammatory cells associated with light-induced photoreceptor degeneration. METHODS. Sprague-Dawley (SD) rats were exposed to 1000 lux light for up to 24 hours, after which some animals were allowed to recover in dim light (5 lux) for 3 or 7 days. During and after exposure to light, the animals were euthanatized and the retinas processed. Ccl2 expression was assessed by qPCR, immunohistochemistry,...[Show more]
|Collections||ANU Research Publications|
|Source:||Investigative Ophthalmology and Visual Science|
|01_Rutar_Early_focal_expression_of_the_2011.pdf||3.14 MB||Adobe PDF|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.