Increasing the antitumor efficacy of doxorubicin-loaded liposomes with peptides anchored via a chelator lipid
The therapeutic efficacy of anticancer drugs like doxorubicin can be significantly increased by their incorporation into liposomes, but an ability to actively target the drug-containing liposomes to tumors could well provide an even greater curative effect. In this work, a commercial preparation of doxorubicin-loaded liposomes (Caelyx) was modified by incorporation of the metal chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA3-DTDA) to enable engraftment of histidine-tagged...[Show more]
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|Source:||Journal of Drug Targeting|
|01_Herringson_Increasing_the_antitumor_2011.pdf||840.46 kB||Adobe PDF||Request a copy|
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