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Increasing the antitumor efficacy of doxorubicin-loaded liposomes with peptides anchored via a chelator lipid

Herringson, Thomas; Altin, Joseph

Description

The therapeutic efficacy of anticancer drugs like doxorubicin can be significantly increased by their incorporation into liposomes, but an ability to actively target the drug-containing liposomes to tumors could well provide an even greater curative effect. In this work, a commercial preparation of doxorubicin-loaded liposomes (Caelyx) was modified by incorporation of the metal chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA3-DTDA) to enable engraftment of histidine-tagged...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/50890
Source: Journal of Drug Targeting
DOI: 10.3109/1061186X.2010.536984

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