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pDNA-lipoplexes engrafted with flagellin-related peptide induce potent immunity and anti-tumour effects

Abdus Salam Abul, Faham; Herringson, Thomas; Parish, Christopher; Suhrbier, Andreas; Khromykh, Alexander A; Altin, Joseph


Complexes of cationic lipids and DNA (lipoplexes) are widely used for non-viral gene delivery and DNA vaccine development, but cationic lipids are toxic and promote non-specific interactions with cells, leading to poor efficacy. Near-neutral lipoplexes, on the other hand, can obviate toxicity, but a convenient means to target them to specific cells such as dendritic cells (DCs) has been lacking. Here, we show that a His-tagged flagellin-derived peptide (denoted 9Flg), previously reported to...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Vaccine
DOI: 10.1016/j.vaccine.2011.07.045


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