pDNA-lipoplexes engrafted with flagellin-related peptide induce potent immunity and anti-tumour effects
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Abdus Salam Abul, Faham; Herringson, Thomas; Suhrbier, Andreas; Khromykh, Alexander A; Altin, Joseph; Parish, Christopher
Description
Complexes of cationic lipids and DNA (lipoplexes) are widely used for non-viral gene delivery and DNA vaccine development, but cationic lipids are toxic and promote non-specific interactions with cells, leading to poor efficacy. Near-neutral lipoplexes, on the other hand, can obviate toxicity, but a convenient means to target them to specific cells such as dendritic cells (DCs) has been lacking. Here, we show that a His-tagged flagellin-derived peptide (denoted 9Flg), previously reported to...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/50846 |
Source: | Vaccine |
DOI: | 10.1016/j.vaccine.2011.07.045 |
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01_Abdus Salam Abul_pDNA-lipoplexes_engrafted_with_2011.pdf | 883.75 kB | Adobe PDF |
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