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Brassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1

Albrecht, Catherine; Boutrot, Freddy; Segonzac, Cecile; Schwessinger, Benjamin; Gimenez-Ibanez, Selena; Chinchilla, Delphine; Rathjen, John; de Vries, Sacco C; Zipfel, Cyril

Description

Plants and animals use innate immunity as a first defense against pathogens, a costly yet necessary tradeoff between growth and immunity. In Arabidopsis, the regulatory leucine-rich repeat receptor-like kinase (LRR-RLK) BAK1 combines with the LRR-RLKs FLS2 and EFR in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and the LRR-RLK BRI1 in brassinosteroid (BR)-mediated growth. Therefore, a potential tradeoff between these pathways mediated by BAK1 is often postulated. Here,...[Show more]

dc.contributor.authorAlbrecht, Catherine
dc.contributor.authorBoutrot, Freddy
dc.contributor.authorSegonzac, Cecile
dc.contributor.authorSchwessinger, Benjamin
dc.contributor.authorGimenez-Ibanez, Selena
dc.contributor.authorChinchilla, Delphine
dc.contributor.authorRathjen, John
dc.contributor.authorde Vries, Sacco C
dc.contributor.authorZipfel, Cyril
dc.date.accessioned2015-12-10T22:15:39Z
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/1885/50789
dc.description.abstractPlants and animals use innate immunity as a first defense against pathogens, a costly yet necessary tradeoff between growth and immunity. In Arabidopsis, the regulatory leucine-rich repeat receptor-like kinase (LRR-RLK) BAK1 combines with the LRR-RLKs FLS2 and EFR in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) and the LRR-RLK BRI1 in brassinosteroid (BR)-mediated growth. Therefore, a potential tradeoff between these pathways mediated by BAK1 is often postulated. Here, we show a unidirectional inhibition of FLS2-mediated immune signaling by BR perception. Unexpectedly, this effect occurred downstream or independently of complex formation with BAK1 and associated downstream phosphorylation. Thus, BAK1 is not rate-limiting in these pathways. BRs also inhibited signaling triggered by the BAK1-independent recognition of the fungal PAMP chitin. Our results suggest a general mechanism operative in plants in which BR-mediated growth directly antagonizes innate immune signaling.
dc.publisherNational Academy of Sciences (USA)
dc.rightsAuthor/s retain copyright
dc.sourcePNAS - Proceedings of the National Academy of Sciences of the United States of America
dc.subjectKeywords: brassinosteroid; brassinosteroid insensitive 1; BRI1 associated Kinase 1; chitin; flagellin; flagellin sensing 2; mitogen activated protein kinase 3; mitogen activated protein kinase 6; protein kinase; unclassified drug; Arabidopsis; article; controlled s Brassinosteroid insensitive 1; BRI1-associated kinase 1; Cross-talk; Flagellin sensing 2
dc.titleBrassinosteroids inhibit pathogen-associated molecular pattern-triggered immune signaling independent of the receptor kinase BAK1
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolumeNovember 15, 2011
dc.date.issued2011
local.identifier.absfor060704 - Plant Pathology
local.identifier.ariespublicationu4956746xPUB210
local.type.statusPublished Version
local.contributor.affiliationAlbrecht, Catherine, Wageningen University
local.contributor.affiliationBoutrot, Freddy, The Sainsbury Laboratory
local.contributor.affiliationSegonzac, Cecile, The Sainsbury Laboratory
local.contributor.affiliationSchwessinger, Benjamin, The Sainsbury Laboratory
local.contributor.affiliationGimenez-Ibanez, Selena, CSIC, The Sainsbury Laboratory
local.contributor.affiliationChinchilla, Delphine , University of Basel
local.contributor.affiliationRathjen, John, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationde Vries, Sacco C , Wageningen University
local.contributor.affiliationZipfel, Cyril, The Sainsbury Laboratory
local.bibliographicCitation.startpage6
local.identifier.doi10.1073/pnas.1109921108
local.identifier.absseo820215 - Vegetables
dc.date.updated2016-02-24T11:27:15Z
local.identifier.scopusID2-s2.0-84856003120
local.identifier.thomsonID000298876500060
dcterms.accessRightsOpen Access
CollectionsANU Research Publications

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