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IL-10-Dependent S100A8 Gene Induction in Monocytes/Macrophages by Double-Stranded RNA1

Endoh, Yasumi; Chung, Yuen Ming; Clark, Ian A; Geczy, Carolyn; Hsu, Kenneth


The S100 calcium-binding proteins S100A8 and S100A9 are elevated systemically in patients with viral infections. The S100A8-S100A9 complex facilitated viral replication in human CD4+ T lymphocytes latently infected with HIV-1- and S100A8-induced HIV-1 transcriptional activity. Mechanisms inducing the S100 genes and the potential source of these proteins following viral activation are unknown. In this study, we show that S100A8 was induced in murine macrophages, and S100A8 and S100A9 in human...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.0802683


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