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Alternative Cyclin D1 Splice Forms Differentially Regulate the DNA Damage Response

Li, Zhiping; Jiao, Xuanmao; Wang, Chenguang; Shirley, Andrew; Elsaleh, Hany; Dahl, Olav; Wang, Min; Soutoglou, Evi; Knudsen, Erik; Pestell, Richard


The DNA damage response (DDR) activates downstream pathways including cell cycle checkpoints. The cyclin D1 gene is overexpressed or amplified in many human cancers and is required for gastrointestinal, breast, and skin tumors in murine models. A common polymorphism in the human cyclin D1 gene is alternatively spliced, resulting in cyclin D1a and D1b proteins that differ in their carboxyl terminus. Cyclin D1 overexpression enhances DNA damage-induced apoptosis. The role of cyclin D1 and the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Cancer Research
DOI: 10.1158/0008-5472.CAN-10-0312


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