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Single-molecule studies of fork dynamics in Escherichia coli DNA replication

Tanner, Nathan A; Hamdan, Samir; Jergic, Slobodan; Loscha, Karin; Schaeffer, Patrick; Dixon, Nicholas; van Oijen, Antoine M

Description

We present single-molecule studies of the Escherichia coli replication machinery. We visualize individual E. coli DNA polymerase III (Pol III) holoenzymes engaging in primer extension and leading-strand synthesis. When coupled to the replicative helicase

dc.contributor.authorTanner, Nathan A
dc.contributor.authorHamdan, Samir
dc.contributor.authorJergic, Slobodan
dc.contributor.authorLoscha, Karin
dc.contributor.authorSchaeffer, Patrick
dc.contributor.authorDixon, Nicholas
dc.contributor.authorvan Oijen, Antoine M
dc.date.accessioned2015-12-10T22:15:26Z
dc.identifier.issn1545-9993
dc.identifier.urihttp://hdl.handle.net/1885/50659
dc.description.abstractWe present single-molecule studies of the Escherichia coli replication machinery. We visualize individual E. coli DNA polymerase III (Pol III) holoenzymes engaging in primer extension and leading-strand synthesis. When coupled to the replicative helicase
dc.publisherNature Publishing Group
dc.sourceNature Structural and Molecular Biology
dc.subjectKeywords: DNA polymerase; DNA primase; DnaB helicase; holoenzyme; article; controlled study; DNA replication; Escherichia coli; nonhuman; priority journal; protein protein interaction; DNA Polymerase III; DNA Replication; DNA, Bacterial; DnaB Helicases; Endodeoxyri
dc.titleSingle-molecule studies of fork dynamics in Escherichia coli DNA replication
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume15
dc.date.issued2008
local.identifier.absfor060107 - Enzymes
local.identifier.absfor060109 - Proteomics and Intermolecular Interactions (excl. Medical Proteomics)
local.identifier.ariespublicationu4005981xPUB208
local.type.statusPublished Version
local.contributor.affiliationTanner, Nathan A, Harvard Medical School
local.contributor.affiliationHamdan, Samir, Harvard Medical School
local.contributor.affiliationJergic, Slobodan, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationLoscha, Karin, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSchaeffer, Patrick, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationDixon, Nicholas, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationvan Oijen, Antoine M, Harvard Medical School
local.description.embargo2037-12-31
local.bibliographicCitation.issue2
local.bibliographicCitation.startpage170
local.bibliographicCitation.lastpage176
local.identifier.doi10.1038/nsmb.1381
dc.date.updated2015-12-09T08:16:47Z
local.identifier.scopusID2-s2.0-38849174361
local.identifier.thomsonID000252932400017
CollectionsANU Research Publications

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