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Single-molecule studies of fork dynamics in Escherichia coli DNA replication

Tanner, Nathan A; Hamdan, Samir; Jergic, Slobodan; Loscha, Karin; Schaeffer, Patrick; Dixon, Nicholas; van Oijen, Antoine M


We present single-molecule studies of the Escherichia coli replication machinery. We visualize individual E. coli DNA polymerase III (Pol III) holoenzymes engaging in primer extension and leading-strand synthesis. When coupled to the replicative helicase

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Nature Structural and Molecular Biology
DOI: 10.1038/nsmb.1381


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