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TCR down-regulation boosts T cell-mediated cytotoxicity and protection against poxvirus infections

Hansen, Ann K; Regner, Matthias; Bonefeld, Charlotte M; Boding, Lasse; Kongsbak, Martin; Odum, Niels; Mullbacher, Arno; Geisler, Carsten; von Essen, Marina R

Description

Cytotoxic T (Tc) cells play a key role in the defense against virus infections. Tc cells recognize infected cells via the T-cell receptor (TCR) and subsequently kill the target cells by one or more cytotoxic mechanisms. Induction of the cytotoxic mechanisms is finely tuned by the activation signals from the TCR. To determine whether TCR down-regulation affects the cytotoxicity of Tc cells, we studied TCR down-regulation-deficient CD3γLLAA mice. We found that Tc cells from CD3γLLAA mice have...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/50450
Source: European Journal of Immunology
DOI: 10.1002/eji.201141413

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