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Neurodevelopmental outcomes of extremely premature infants conceived after assisted conception: a population based cohort study

Mohamed, Abdel-Latif; Bajuk, Barbara; Ward, Meredith; Oei, Ju Lee; Badawi, Nadia

Description

To compare neurodevelopmental outcomes of extremely preterm infants conceived after assisted conception (AC) compared with infants conceived spontaneously (non-AC). Population-based retrospective cohort study. Geographically defined area in New South Wales and the Australian Capital Territory, Australia served by a network of 10 neonatal intensive care units. Infants <29 weeks' gestation born between 1998 and 2004. At 2-3 years corrected age, 1473 children were assessed with either the...[Show more]

dc.contributor.authorMohamed, Abdel-Latif
dc.contributor.authorBajuk, Barbara
dc.contributor.authorWard, Meredith
dc.contributor.authorOei, Ju Lee
dc.contributor.authorBadawi, Nadia
dc.date.accessioned2015-12-10T22:14:53Z
dc.identifier.issn1468-2052
dc.identifier.urihttp://hdl.handle.net/1885/50367
dc.description.abstractTo compare neurodevelopmental outcomes of extremely preterm infants conceived after assisted conception (AC) compared with infants conceived spontaneously (non-AC). Population-based retrospective cohort study. Geographically defined area in New South Wales and the Australian Capital Territory, Australia served by a network of 10 neonatal intensive care units. Infants <29 weeks' gestation born between 1998 and 2004. At 2-3 years corrected age, 1473 children were assessed with either the Griffiths Mental Developmental Scales or the Bayley Scales of Infant Development. Moderate/severe functional disability defined as developmental delay (Griffiths General Quotient or Bayley Mental Developmental Index >2 SD below the mean), cerebral palsy (unable to walk without aids), deafness (bilateral hearing aids or cochlear implant) or blindness (visual acuity <6/60 in the better eye). Mortality and age at follow-up were comparable between the AC and non-AC groups. Developmental outcome was evaluated in 217 (86.5%) AC and 1256 (71.7%) non-AC infants. Using multivariate adjusted analysis, infants born after in-vitro fertilisation at 22-26 weeks' gestation (adjusted OR 1.79, 95% CI 1.05 to 3.05, p=0.03) but not at 27-28 weeks' gestation (adjusted OR 0.81, 95% CI 0.37 to 1.77; p=0.59) had higher rate of functional disability than those born after spontaneous conception. AC is associated with adverse neurodevelopmental outcome among high risk infants born at 22-26 weeks' gestation. This finding warrants additional exploration.
dc.publisherB M J Group
dc.sourceArchives of Disease in Childhood. Fetal and Neonatal Edition
dc.subjectKeywords: adult; article; Australia; cohort analysis; developmental disorder; disability; female; follow up; growth, development and aging; human; infertility therapy; mortality; newborn; newborn intensive care; outcome assessment; pregnancy; prematurity; prospecti
dc.titleNeurodevelopmental outcomes of extremely premature infants conceived after assisted conception: a population based cohort study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolumeEpub ahead of print
dc.date.issued2012
local.identifier.absfor111400 - PAEDIATRICS AND REPRODUCTIVE MEDICINE
local.identifier.ariespublicationu4971216xPUB202
local.type.statusPublished Version
local.contributor.affiliationMohamed, Abdel-Latif, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBajuk, Barbara, NSW Pregnancy and Newborn Services Network
local.contributor.affiliationWard, Meredith, University of New South Wales
local.contributor.affiliationOei, Ju Lee, University of New South Wales
local.contributor.affiliationBadawi, Nadia, University of Sydney
local.description.embargo2037-12-31
local.bibliographicCitation.startpage1
local.bibliographicCitation.lastpage9
local.identifier.doi10.1136/archdischild-2012-302040
dc.date.updated2016-02-24T11:31:36Z
local.identifier.scopusID2-s2.0-84879513450
CollectionsANU Research Publications

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