Skip navigation
Skip navigation

Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction

Pathmaperuma, Arjuna; Mana, Paula; Cheung, Stephanie; Kugathas, Kavitha; Josiah, Angeline; Koina, Mark; Broomfield, Amy; Delghingaro-Augusto, Viviane; Ellwood, David; Dahlstrom, Jane; Nolan, Christopher


The diabetic pregnancy is characterized by maternal hyperglycaemia and dyslipidaemia, such that placental trophoblast cells are exposed to both. The objective was to determine the effects of hyperglycaemia, elevated non-esterified fatty acids (NEFA) and their interactions on trophoblast cell metabolism and function. Trophoblasts were isolated from normal term human placentas and established in culture for 16 h prior to experiments. Glucose utilisation, fatty acid oxidation and fatty acid...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Placenta
DOI: 10.1016/j.placenta.2009.12.013


File Description SizeFormat Image
01_Pathmaperuma_Fatty_acids_alter_glycerolipid_2010.pdf1.66 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator