Fatty acids alter glycerolipid metabolism and induce lipid droplet formation, syncytialisation and cytokine production in human trophoblasts with minimal glucose effect or interaction
Pathmaperuma, Arjuna; Mana, Paula; Cheung, Stephanie; Kugathas, Kavitha; Josiah, Angeline; Koina, Mark; Broomfield, Amy; Delghingaro-Augusto, Viviane; Ellwood, David; Nolan, Christopher; Dahlstrom, Jane
The diabetic pregnancy is characterized by maternal hyperglycaemia and dyslipidaemia, such that placental trophoblast cells are exposed to both. The objective was to determine the effects of hyperglycaemia, elevated non-esterified fatty acids (NEFA) and their interactions on trophoblast cell metabolism and function. Trophoblasts were isolated from normal term human placentas and established in culture for 16 h prior to experiments. Glucose utilisation, fatty acid oxidation and fatty acid...[Show more]
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