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Pivotal Role of Antibody and Subsidiary Contribution of CD8+ T Cells to Recovery from Infection in a Murine Model of Japanese Encephalitis

Larena, Maximilian; Regner, Matthias; Lee, Eva; Lobigs, Mario


The immunological correlates for recovery from primary Japanese encephalitis virus (JEV) infection in humans and experimental animals remain poorly defined. To investigate the relative importance of the adaptive immune responses, we have established a mouse model for Japanese encephalitis in which a low-dose virus inoculum was administered into the footpads of adult C57BL/6 mice. In this model, ~60% of the mice developed a fatal encephalitis and a virus burden in the central nervous system...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.02611-10


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