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Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders

Rahimi, Ahmed (Farid); Shanmugam, A; Bitan, Gal


Several neurodegenerative diseases, including Alzheimer's, Parkinson's, Huntington's and prion diseases, are characterized pathognomonically by the presence of intra- and/or extracellular lesions containing proteinaceous aggregates, and by extensive neuronal loss in selective brain regions. Related non-neuropathic systemic diseases, e.g., light-chain and senile systemic amyloidoses, and other organ-specific diseases, such as dialysis-related amyloidosis and type-2 diabetes mellitus, also are...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Current Alzheimer Research
DOI: 10.2174/156720508784533358


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