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B-cell development: One problem, multiple solutions

Alitheen, Noorjahan; McClure, Susan J; McCullagh, Peter


Interspecies variations in the processes of B-cell development and repertoire generation contrast with the greater consistency of T-cell development. B-cell development in mice and humans, with postnatal B-cell generation of new repertoire in the bone marrow throughout life, is regarded as the standard pattern. In contrast, accounts of B cells in birds, sheep, cattle, rabbits and pigs (the other species) describe cessation of gene diversification in the perinatal period, with the gut-associated...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/icb.2009.119


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