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Heterophile interference accounts for method-specific dsDNA antibodies in patients receiving anti-TNF treatment

Alshekaili, Jalila; Li, Candice; Cook, Matthew


To evaluate analytical explanations for the highly reported incidence of antibodies to dsDNA in patients receiving TNF antagonists. Sixty serum samples from patients receiving biological anti-TNF medication were assessed for the presence of dsDNA antibodies using three standard diagnostic platforms [ELISA, IIF and multiplex bead array (MBA)], before and after treatment to block heterophile antibodies. Results were compared with those obtained using serum samples from patients with SLE. We...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Rheumatology
DOI: 10.1093/rheumatology/keq018


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