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S100A8 and S100A9 in human arterial wall

McCormick, Michelle M; Rahimi, Ahmed (Farid); Bobryshev, Yuri V; Gaus, Katharina; Zreiqat, Hala; Cai, Hong; Lord, Reginald S A; Geczy, Carolyn


Atherogenesis is a complex process involving inflammation. S100A8 and S100A9, the Ca2+-binding neutrophil cytosolic proteins, are associated with innate immunity and regulate processes leading to leukocyte adhesion and transmigration. In neutrophils and monocytes the S100A8-S100A9 complex regulates phosphorylation, NADPH-oxidase activity, and fatty acid transport. The proteins have anti-microbial properties, and S100A8 may play a role in oxidant defense in inflammation. Murine S100A8 is...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M509442200


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