Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo
Extrafollicular (EF) B-cell responses are increasingly being recognized as an alternative pathway of B-cell activation, particularly in autoimmunity. Critical cellular interactions required for the EF Bcell response are unclear. A key question in autoimmunity, in which Toll-like receptor (TLR) signals are costimulatory and could be sufficient for B-cell activation, is whether T cells are required for the response. This is pivotal, because autoreactive B cells are considered antigen-presenting...[Show more]
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|Source:||PNAS - Proceedings of the National Academy of Sciences of the United States of America|
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