Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo
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Sweet, Rebecca; Ols, Michael L.; Cullen, J; Milam, Ashley V.; Yagita, Hideo; Shlomchik, M J
Description
Extrafollicular (EF) B-cell responses are increasingly being recognized as an alternative pathway of B-cell activation, particularly in autoimmunity. Critical cellular interactions required for the EF Bcell response are unclear. A key question in autoimmunity, in which Toll-like receptor (TLR) signals are costimulatory and could be sufficient for B-cell activation, is whether T cells are required for the response. This is pivotal, because autoreactive B cells are considered antigen-presenting...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/50100 |
Source: | PNAS - Proceedings of the National Academy of Sciences of the United States of America |
DOI: | 10.1073/pnas.1018571108 |
Access Rights: | Open Access |
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01_Sweet_Facultative_role_for_T_cells_2011.pdf | 571.44 kB | Adobe PDF |
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