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Regulation of S100A8 by Glucocorticoids

Hsu, Kenneth; Passey, Robert J; Endoh, Yasumi; Rahimi, Ahmed (Farid); Youssef, Peter; Yen, Tina; Geczy, Carolyn

Description

S100A8 (A8) has roles in inflammation, differentiation and development and is associated with oxidative defense. Murine A8 (mA8) is up-regulated in macrophages, fibroblasts, and microvascular endothelial cells by LPS. Glucocorticoids (GCs) amplified LPS-induced mA8 in these cells. Relative to stimulation by LPS, GCs increased mA8 gene transcription and mRNA half-life. Enhancement required new protein synthesis, IL-10 and products of the cyclooxygenase-2 pathway, and both ERK1/2 and p38 MAPK....[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/50051
Source: Journal of Immunology

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