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A new site-directed transgenic rheumatoid factor mouse model demonstrates extrafollicular class switch and plasmablast formation

Sweet, Rebecca; Christensen, Sean R.; Harris, Michelle L.; Shupe, Jonathan; Sutherland, Jamie L.; Shlomchik, M J


The AM14 rheumatoid factor (RF) transgenic (Tg) mouse has been valuable for studying how self-reactive B cells are regulated beyond central tolerance, because they remain ignorant in normal mice. AM14 B-cell activation can be studied on autoimmune-prone strains or by inducing activation with IgG2a anti-chromatin antibodies (Abs). Despite the utility of conventional Ig-Tg mice, site-directed Ig-Tg (sd-Tg) mice provide a more physiological model for B-cell responses, allowing class switch and...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Autoimmunity
DOI: 10.3109/08916930903567500


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