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Effect of Model Choice in Genetic Association Studies: DRD4 Exon III VNTR and Cigarette Use in Young Adults

Das, Debjani; Tan, Susan (Xiaoyun); Easteal, Simon

Description

A major concern with the vast literature associating the highly polymorphic 48 bp VNTR in exon III of the human dopamine receptor D4 gene (DRD4) with various behavioral phenotypes is the lack of concordance between studies. Part of the problem arises from the absence of a universally accepted scheme for pooling the large number of low frequency genotypes into appropriate categories. Here, we investigated the effect of different pooling strategies and genetic models on the reported association...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/50019
Source: American Journal of Medical Genetics, Part B: Neuropsychiatric
DOI: 10.1002/ajmg.b.31169

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