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T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells

Herlands, Robin A.; Christensen, Sean R.; Sweet, Rebecca; Hershberg, Uri; Shlomchik, M J


On the lupus-prone MRL-lpr/lpr (MRL-lpr) background, AM14 rheumatoid factor (RF) B cells are activated, differentiate into plasmablasts, and undergo somatic hypermutation outside of follicles. Using multiple strategies to impair T cells, we found that su

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Immunity
DOI: 10.1016/j.immuni.2008.06.009


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