Pleiotropic roles of S100A12 in coronary atherosclerotic plaque formation and rupture
Goyette, Jesse; Yan, Wei Xing; Yamen, Eric; Chung, Yuen Ming; Lim, Su Yin; Hsu, Kenneth; Rahimi, Ahmed (Farid); Di Girolamo, Nick; Song, Changjie; Jessup, Wendy; Kockx, Maaike; Bobryshev, Yuri V; Freedman, S Ben; Geczy, Carolyn
Macrophages, cytokines, and matrix metalloproteinases (MMP) play important roles in atherogenesis. The Ca2+-binding protein S100A12 regulates monocyte migration and may contribute to atherosclerosis by inducing proinflammatory cytokines in macrophages. We found significantly higher S100A12 levels in sera from patients with coronary artery disease than controls and levels correlated positively with C-reactive protein. S100A12 was released into the coronary circulation from ruptured plaque in...[Show more]
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|Source:||Journal of Immunology|
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