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Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression

Farrell, Geoffrey; Larter, Claire; Hou, Jing Yun; Zhang, Rena H; Yeh, Matthew; Williams, Jacqueline; dela Pena, Aileen; Francisco, Rona; Osvath, Sarah; Brooling, John; Teoh, Narcissus; Sedger, Lisa


Background and Aims: We examined extrinsic and intrinsic (endogenous) mitochondrial apoptosis pathways in experimental non-alcoholic steatohepatitis (NASH). Methods: To assess extrinsic pathways, we measured hepatic expression of death-inducing cytokine receptors (tumor necrosis factor-α-receptor (TNF-R)1, TNF-R2, Fas, and TNFα-related apoptosis-inducing ligand-receptor (TRAIL-R) mRNA, TUNEL, caspase 3 activation, liver injury and liver pathology in mice fed a methionine and choline deficient...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Gastroenterology and Hepatology
DOI: 10.1111/j.1440-1746.2009.05785.x


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