Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression
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Hui, Jason M; Sud, Archana; Farrell, Geoffrey; Bandara, Priyanka; Byth, Karen; Kench, James; McCaughan, Geoffrey W; George, Jacob
Description
Background & Aims: Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection. Methods: In 260 hepatitis C virus-infected subjects, we examined the relationship between histological findings and anthropometric and biochemical data, including insulin resistance determined by the homeostasis model assessment (HOMA-IR). We also...[Show more]
dc.contributor.author | Hui, Jason M | |
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dc.contributor.author | Sud, Archana | |
dc.contributor.author | Farrell, Geoffrey | |
dc.contributor.author | Bandara, Priyanka | |
dc.contributor.author | Byth, Karen | |
dc.contributor.author | Kench, James | |
dc.contributor.author | McCaughan, Geoffrey W | |
dc.contributor.author | George, Jacob | |
dc.date.accessioned | 2015-12-10T22:13:46Z | |
dc.identifier.issn | 0016-5085 | |
dc.identifier.uri | http://hdl.handle.net/1885/49912 | |
dc.description.abstract | Background & Aims: Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection. Methods: In 260 hepatitis C virus-infected subjects, we examined the relationship between histological findings and anthropometric and biochemical data, including insulin resistance determined by the homeostasis model assessment (HOMA-IR). We also compared fasting serum insulin, C peptide, and HOMA-IR levels between the subset of 121 hepatitis C virus patients with stage 0 or 1 hepatic fibrosis and 137 healthy volunteers matched by sex, body mass index, and waist-hip ratio. Results: Hepatitis C virus-infected subjects with stage 0 or 1 hepatic fibrosis had higher levels of insulin, C peptide, and HOMA-IR (all P ≤ 0.01) compared with matched healthy controls. In the 250 hepatitis C virus patients (fibrosis stage 0 to 4), viral genotype and portal, but not lobular, inflammation were univariate predictors of HOMA-IR. By multiple linear regression analysis, independent predictors of HOMA-IR included body mass index (P < 0.1001), previous failed antiviral treatment (P < 0.001), portal inflammatory grade (P < 0.001), and genotype 3 status (P = 0.01). Genotype 3 had significantly lower HOMA-IR than other genotypes (which were comparable when adjusted for effects of the remaining independent predictors). HOMA-IR was an independent predictor for the degree of fibrosis (P < 0.001) and the rate of fibrosis progression (P = 0.03). Conclusions: Hepatitis C virus may induce insulin resistance irrespective of the severity of liver disease, and this effect seems to be genotype specific. Further, our findings support the hypothesis that insulin resistance may contribute to fibrotic progression in chronic hepatitis C virus infection. | |
dc.publisher | W B Saunders Co | |
dc.source | Gastroenterology | |
dc.subject | Keywords: antivirus agent; C peptide; glucose; insulin; interferon; ribavirin; adolescent; adult; aged; anthropometric parameters; article; body mass; controlled study; correlation analysis; disease association; disease course; disease severity; female; fibrogenesi | |
dc.title | Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 125 | |
dc.date.issued | 2003 | |
local.identifier.absfor | 110300 - CLINICAL SCIENCES | |
local.identifier.ariespublication | u4222028xPUB194 | |
local.type.status | Published Version | |
local.contributor.affiliation | Hui, Jason M, University of Sydney, Westmead Hospital | |
local.contributor.affiliation | Sud, Archana, University of Sydney | |
local.contributor.affiliation | Farrell, Geoffrey, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Bandara, Priyanka, University of Sydney | |
local.contributor.affiliation | Byth, Karen, Westmead Hospital | |
local.contributor.affiliation | Kench, James, University of Sydney, Westmead Hospital | |
local.contributor.affiliation | McCaughan, Geoffrey W, Royal Prince Alfred Hospital | |
local.contributor.affiliation | George, Jacob, University of Sydney | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 1695 | |
local.bibliographicCitation.lastpage | 1704 | |
local.identifier.doi | 10.1053/j.gastro.2003.08.032 | |
dc.date.updated | 2015-12-09T07:59:38Z | |
local.identifier.scopusID | 2-s2.0-0345655291 | |
Collections | ANU Research Publications |
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