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The Ig-like domain of human GM-CSF receptor α plays a critical role in cytokine binding and receptor activation

Mirza, Shamaruh; Walker, Andrew; Chen, Jinglong; Murphy, James M; Young, Ian

Description

GM-CSF (granulocyte/macrophage colony-stimulating factor) is an important mediator of inducible haemopoiesis and inflammation, and has a critical role in the function of alveolar macrophages. Its clinical applications include the mobilization of haemopoietic progenitors, and a role as an immune stimulant and vaccine adjuvant in cancer patients. GM-CSF signals via a specific α receptor (GM-CSFRα) and the shared hβc (human common β-subunit). The present study has investigated the role of the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/49890
Source: Biochemical Journal
DOI: 10.1042/BJ20091745

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