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Inhibition of COXs and 5-LOX and activation of PPARs by Australian Clematis species (Ranunculaceae)

Li, Rachel; Lin, David G; Leach, D N; Waterman, P G; Myers, S P


The species of Clematis (Ranunculaceae) have been traditionally used for inflammatory conditions by indigenous Australians. We have previously reported that the ethanol extract of Clematis pickeringii inhibited COX-1. In this study, we examined the ethanol extracts and fractions of three Clematis species, Clematis pickeringii, Clematis glycinoides and Clematis microphylla, on cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX). We further examined the activating...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Ethnopharmacology
DOI: 10.1016/j.jep.2005.08.061


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