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Primary immune deficiencies affecting lymphocyte differentiation: lessons from the spectrum of resulting infections

Cook, Matthew; Tangye, Stuart G


Understanding primary immunodeficiencies has elucidated many aspects of human immunity and susceptibility to infections. Recently, defects have been identified that result in deficiencies of terminally differentiated subsets of lymphocytes including deficiencies of memory B cells, NKT cells and Th17 T cells. Together with defects specific to Th1 responses, these disorders revealed that dedicated pathogen-specific mechanisms exist for prevalent human pathogens, and that some host defence...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: International Immunology
DOI: 10.1093/intimm/dxp076


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