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Genome-wide identification of human FOXP3 target genes in natural regulatory T cells

Sadlon, Timothy J; Wilkinson, Bridget G; Pederson, Stephen; Brown, Cheryl Y; Bresatz, Suzanne; Gargett, Tessa; Melville, Elizabeth L; Peng, Kaimen; D'Andrea, Richard J; Glonek, Gary G; Goodall, Gregory J; Zola, Heddy; Shannon, M Frances; Barry, Simon C

Description

The transcription factor FOXP3 is essential for the formation and function of regulatory T cells (Tregs), and Tregs are essential for maintaining immune homeostasis and tolerance. This is demonstrated by a lethal autoimmune defect in mice lacking Foxp3 and in immunodysregulation polyendocrinopathy enteropathy X-linked syndrome patients. However, little is known about the molecular basis of human FOXP3 function or the relationship between direct and indirect targets of FOXP3 in human Tregs. To...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/49672
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1000082

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