Staging bone marrow in diffuse large B-cell lymphoma: the role of ancillary investigations
Diffuse large B-cell lymphoma DLBCL is an aggressive non-Hodgkin's lymphoma NHL that requires treatment at initial diagnosis. Treatment decisions may be guided by staging investigations, which include assessment of bone marrow BM. Traditionally this assessment has included light microscopic examination of the bone marrow aspirate and trephine biopsy. Ancillary testingincluding immunophenotyping using flow cytometry on BM aspirates, immunohistochemistry IHC on BM trephines and molecular studies...[Show more]
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