SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage
Betaine (N,N,N-trimethylglycine) added to culture media is known to substantially improve the development of preimplantation mouse embryos in vitro, and to be imported into 1-cell embryos by a transporter that also accepts proline. Here, we found that the betaine/proline transporter is active in preimplantation mouse embryos only for a short period of development, between the 1- and 2-cell stages. Betaine/proline transport was activated after fertilization, beginning ∼4 hours post-egg...[Show more]
|Collections||ANU Research Publications|
|01_Anas_SIT1_is_a_betaine/proline_2008.pdf||264.41 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.