Histone Variant H2A.Z Can Serve as a New Target for Breast Cancer Therapy
Histone H2A variant, H2A.Z, plays an essential role in transcriptional activation of ERa-dependent genes, cell proliferation, development, and differentiation. High expression of H2A.Z is ubiquitously detected in the progression of breast cancer, and is significantly associated with lymph node metastasis and patient survival. This makes H2A.Z an excellent target for diagnostic and therapeutic interventions. A recent study provides a new insight into the role of H2A.Z within the context of...[Show more]
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|Source:||Current Medicinal Chemistry|
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