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Towards the Assembly of the Binary Vinca Alkaloids: Strategies for the Synthesis of Analogues of the Indole-Indoline Core of (+)- Vinblastine

Harvey, Michael John


The clinically important alkaloids (+)-vinblastine (1) and (+)-vincristine (2) both exhibit extraordinary potency as anti-mitotic agents and act by destabilising polymerised tubulin. While the development of a structure-activity-relationship (SAR) profile around these natural products should allow for the identification of the relevant pharmacophore, this task is especially daunting because of the structural complexity of these compounds. Indeed, most analogues of the Vinca alkaloids are...[Show more]

CollectionsOpen Access Theses
Date published: 2011-01-24T02:52:28Z
Type: Thesis (PhD)


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