T cell deficiencies resulting from aberrant pre-mRNA alternative splicing caused by a novel splicing silencer hnRNP LL in an ENU mutant mouse strain thunder
ENU mutagenesis screening is a phenotype-driven approach to identify genes in a nonbiased manner. Through this approach we identified a previously uncharacterised gene, Hnrpll, which is involved in nascent mRNA alternative splicing. Thunder strain carries a point mutation in the Hnrpll gene (407T->A) in its first RNA recognition motif (RRM) which changes it function in regulating nascent mRNA alternative splicing. One of Hnrpll target genes is CD45 that undergoes alternative splicing in T cells...[Show more]
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