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Prion Protein Gene and Its Shadow

Premzl, Marko


Prion protein (PrP) is best known for its involvement in prion diseases. A normal, dynamic isoform of prion protein (PrP^C) transforms into a pathogenic, compact isoform (PrP^Sc) during prion disease pathogenesis. The PrP^Sc, acting as a template upon which PrP^C molecules are refolded into a likeness of itself, accumulates in the brain neurones and causes disease. It is the only known component of prions, proteinaceous infectious particles. Both prion protein isoforms have the same primary...[Show more]

CollectionsOpen Access Theses
Date published: 2004-09
Type: Thesis (PhD)


File Description SizeFormat Image
01front.pdf285.75 kBAdobe PDFThumbnail
02chapter1.pdf1.9 MBAdobe PDFThumbnail
03chapter2.pdf1.17 MBAdobe PDFThumbnail
04chapter3.pdf188.78 kBAdobe PDFThumbnail
05chapter4.pdf361.54 kBAdobe PDFThumbnail
06chapter5.pdf1.39 MBAdobe PDFThumbnail
07chapter6.pdf1.53 MBAdobe PDFThumbnail
08chapter7.pdf38.29 kBAdobe PDFThumbnail
09references.pdf126.3 kBAdobe PDFThumbnail
10appendixI-III.pdf66.04 kBAdobe PDFThumbnail

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