Prion Protein Gene and Its Shadow
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Description
Prion protein (PrP) is best known for its involvement in prion diseases. A normal, dynamic isoform of prion protein (PrP^C) transforms into a pathogenic, compact isoform (PrP^Sc) during prion disease pathogenesis. The PrP^Sc, acting as a template upon which PrP^C molecules are refolded into a likeness of itself, accumulates in the brain neurones and causes disease. It is the only known component of prions, proteinaceous infectious particles. Both prion protein isoforms have the same primary...[Show more]
Collections | Open Access Theses |
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Date published: | 2004 |
Type: | Thesis (PhD) |
URI: | http://hdl.handle.net/1885/48000 |
DOI: | 10.25911/5d7a2b4659a28 |
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File | Description | Size | Format | Image |
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01front.pdf | 285.75 kB | Adobe PDF | ||
02chapter1.pdf | 1.9 MB | Adobe PDF | ||
03chapter2.pdf | 1.17 MB | Adobe PDF | ||
04chapter3.pdf | 188.78 kB | Adobe PDF | ||
05chapter4.pdf | 361.54 kB | Adobe PDF | ||
06chapter5.pdf | 1.39 MB | Adobe PDF | ||
07chapter6.pdf | 1.53 MB | Adobe PDF | ||
08chapter7.pdf | 38.29 kB | Adobe PDF | ||
09references.pdf | 126.3 kB | Adobe PDF | ||
10appendixI-III.pdf | 66.04 kB | Adobe PDF |
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