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Simulation Studies of Biological Ion Channels

Corry, Ben Alexander

Description

Biological ion channels are responsible for, and regulate the communication system in the body. In this thesis I develop, test and apply theoretical models of ion channels, that can relate their structure to their functional properties. Brownian dynamics simulations are introduced, in which the motions of individual ions are simulated as they move through the channel and in baths attached to each end. The techniques for setting boundary conditions which maintain ion concentrations in the baths...[Show more]

dc.contributor.authorCorry, Ben Alexander
dc.date.accessioned2008-03-11T03:15:54Z
dc.date.accessioned2011-01-04T02:37:48Z
dc.date.available2008-03-11T03:15:54Z
dc.date.available2011-01-04T02:37:48Z
dc.identifier.otherb21432946
dc.identifier.urihttp://hdl.handle.net/1885/46252
dc.description.abstractBiological ion channels are responsible for, and regulate the communication system in the body. In this thesis I develop, test and apply theoretical models of ion channels, that can relate their structure to their functional properties. Brownian dynamics simulations are introduced, in which the motions of individual ions are simulated as they move through the channel and in baths attached to each end. The techniques for setting boundary conditions which maintain ion concentrations in the baths and provide a driving potential are tested. Provided the bath size is large enough, all boundary conditions studied yield the same results. ...
dc.language.isoen
dc.rights.uriThe Australian National University
dc.subjectbiophysics
dc.subjection channels
dc.subjectcomputer simulation
dc.subjectstochastic dynamics
dc.subjectcontinuum electrostatics
dc.subjectbiological simulation
dc.titleSimulation Studies of Biological Ion Channels
dc.typeThesis (PhD)
dcterms.valid2003
local.description.refereedyes
local.type.degreeDoctor of Philosophy (PhD)
dc.date.issued2002
local.contributor.affiliationThe Australian National University
local.contributor.affiliationResearch School of Physical Sciences and Engineering
local.identifier.doi10.25911/5d7a2aa2eaf7c
local.mintdoimint
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04chapters7-9.pdf2.55 MBAdobe PDFThumbnail


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