Skip navigation
Skip navigation

The impact of HIV on morbidity and mortality from tuberculosis in sub-Saharan Africa: a study of rural Malawi and review of the literature

Glynn, J. R; Warndorff, D. K; Fine, P. E. M; Msiska, G. K; Munthali, M. M; Ponnighaus, J. M

Description

Since the mid-1980s tuberculosis (TB) case numbers and HIV seroprevalence have both risen sharply in sub-Saharan Africa. Estimates for the relative risk of TB in those infected with HIV have ranged from less than five to more than 20. The proportion of TB cases attributable to HIV (the population attributable fraction) has been calculated for several populations but is difficult to interpret if no account is taken of the age and sex distribution of the cases. In a rural area of Malawi we have...[Show more]

dc.contributor.authorGlynn, J. R
dc.contributor.authorWarndorff, D. K
dc.contributor.authorFine, P. E. M
dc.contributor.authorMsiska, G. K
dc.contributor.authorMunthali, M. M
dc.contributor.authorPonnighaus, J. M
dc.contributor.editorAwusabo-Asare, Kofi
dc.contributor.editorPisani, Elisabeth
dc.contributor.editorBoerma, J. Ties
dc.contributor.editorZaba, Basia
dc.date.accessioned2003-03-12
dc.date.accessioned2004-05-19T15:25:41Z
dc.date.accessioned2011-01-05T08:36:14Z
dc.date.available2004-05-19T15:25:41Z
dc.date.available2011-01-05T08:36:14Z
dc.date.created1997
dc.identifier.urihttp://hdl.handle.net/1885/41321
dc.identifier.urihttp://digitalcollections.anu.edu.au/handle/1885/41321
dc.description.abstractSince the mid-1980s tuberculosis (TB) case numbers and HIV seroprevalence have both risen sharply in sub-Saharan Africa. Estimates for the relative risk of TB in those infected with HIV have ranged from less than five to more than 20. The proportion of TB cases attributable to HIV (the population attributable fraction) has been calculated for several populations but is difficult to interpret if no account is taken of the age and sex distribution of the cases. In a rural area of Malawi we have studied the proportion of TB attributable to HIV over time. Nearly 40 per cent of smear-positive TB cases in this rural area of Malawi can now be attributed directly to HIV. The actual effect of HIV on TB is even greater than this because increased case numbers increase transmission of tuberculosis infection to both HIV-infected and non-infected sections of the population. We compare our findings with others from sub-Saharan Africa and discuss reasons for the differences, and methodological issues in interpretation
dc.format.extent53612 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherHealth Transition Centre, National Centre for Epidemiology and Population Health, The Australian National University
dc.subjectAfrica
dc.subjectMalawi
dc.subjectHIV/AIDS
dc.subjectmorbidity
dc.subjectmortality
dc.subjecttuberculosis
dc.subjectTB
dc.titleThe impact of HIV on morbidity and mortality from tuberculosis in sub-Saharan Africa: a study of rural Malawi and review of the literature
dc.typeJournal article
local.description.refereedno
local.identifier.citationnumbersupp.2
local.identifier.citationpages75-87
local.identifier.citationpublicationHealth Transition Review
local.identifier.citationvolume7
local.identifier.citationyear1997
local.identifier.eprintid943
local.rights.ispublishedyes
dc.date.issued1997
CollectionsANU Research Publications

Download

File Description SizeFormat Image
Glynn1.pdf52.36 kBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator