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Antigen-specific activation thresholds of CD8+ T cells are independent of IFN-I-mediated partial lymphocyte activation

Wijesundara, Danushka; Kumar, Sheetal; Alsharifi, Mohammed; Mullbacher, Arno; Regner, Matthias


Type-I IFN (IFN-I) are highly pleiotropic cytokines known to modulate immune responses and play an early central role in mediating antiviral defenses. We have shown that IFN-I mediate transient up-regulation of a distinct subset of lymphocyte surface activation markers on both B and T cells in vivo independent of cognate antigen: a state referred to as 'partial lymphocyte activation'. Here we investigated in vitro the possibility that partial lymphocyte activation may serve to lower the...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: International Immunology
DOI: 10.1093/intimm/dxq064


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