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VEGF Expression by Ganglion cells in Central Retina before formation of the Foveal Depression in Monkey retina: Evidence of Developmental Hypoxia

Sandercoe, Trent M; Geller, Scott; Hendrickson, Anita E; Stone, Jonathan; Provis, Jan


In macaque monkeys the foveal depression forms between fetal day (Fd) 105 and birth (Fd 172 of gestation). Before this, the incipient fovea is identified by a photoreceptor layer comprising cones almost exclusively, a multilayered ganglion cell layer (GCL), and a "domed" profile. Vessels are absent from the central retina until late in development, leading to the suggestion that the GCL in the incipient fovea may be transitorily hypoxic. Vascular endothelial growth factor (VEGF), expressed by...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Comparative Neurology
DOI: 10.1002/cne.10705


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