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Indomethacin, ibuprofen and gentamicin administered during late stages of glomerulogenesis do not reduce glomerular number at 14 days of age in the neonatal rat

Kent, Alison; Douglas-Denton, Rebecca; Shadbolt, Bruce; Maxwell, Lesley; Konia, Mark E; Falk, Michael C; Willenborg, David; Bertram, John; Dahlstrom, Jane


Premature neonates are frequently administered indomethacin, ibuprofen and gentamicin during the period of active glomerulogenesis. These drugs are known to have nephrotoxic effects, but the morphological effect of these drugs is unknown. The purpose of this study was to determine whether administration of these drugs during the late stages of glomerulogenesis in the rat has an effect on glomerular endowment. Rat pups were given, intraperitoneally, indomethacin, ibuprofen or indomethacin and...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Pediatric Nephrology
DOI: 10.1007/s00467-008-1114-5


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