Lobigs, Mario; Pavy, Megan; Hall, Roy A; Lobigs, Paivi; Cooper, Peter; Komiya, Tomoyoshi; Toriniwa, Hiroko; Petrovsky, Nikolai
Advax is a polysaccharide-based adjuvant that potently stimulates vaccine immunogenicity without the increased reactogenicity seen with other adjuvants. This study investigated the immunogenicity of a novel Advax-adjuvanted Vero cell culture candidate vaccine against Japanese encephalitis virus (JEV) in mice and horses. The results showed that, in mice, a two-immunization, low-dose (50 ng JEV antigen) regimen with adjuvanted vaccine produced solid neutralizing immunity comparable to that...[Show more]
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