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An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses

Lobigs, Mario; Pavy, Megan; Hall, Roy A; Lobigs, Paivi; Cooper, Peter; Komiya, Tomoyoshi; Toriniwa, Hiroko; Petrovsky, Nikolai


Advax is a polysaccharide-based adjuvant that potently stimulates vaccine immunogenicity without the increased reactogenicity seen with other adjuvants. This study investigated the immunogenicity of a novel Advax-adjuvanted Vero cell culture candidate vaccine against Japanese encephalitis virus (JEV) in mice and horses. The results showed that, in mice, a two-immunization, low-dose (50 ng JEV antigen) regimen with adjuvanted vaccine produced solid neutralizing immunity comparable to that...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of General Virology
DOI: 10.1099/vir.0.019190-0


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