Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum
Purines enter the intraerythrocytic malaria parasite via a fast, low-affinity, broad-capacity process that can be attributed primarily to the parasite plasma membrane transporter PfNT1. The reliance of the parasite on PfNT1 makes this protein a worthy target for further investigation, while the determination of the roles played by PfNT2, PfNT3, and PfNT4 in parasite physiology should also prove interesting. Within the parasite, the metabolism of purines appears to be funneled through...[Show more]
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