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Acid extrusion from the intraerythrocytic malaria parasite is not via a Na+/H+ exchanger

Spillman, Natalie; Allen, Richard; Kirk, Kiaran


The intraerythrocytic malaria parasite, Plasmodium falciparum maintains an intracellular pH (pHi) of around 7.3. If subjected to an experimentally imposed acidification the parasite extrudes H+, thereby undergoing a pHi recovery. In a recent study, Bennett et al. [Bennett TN, Patel J, Ferdig MT, Roepe PD. P. falciparum Na+/H+ exchanger activity and quinine resistance. Mol Biochem Parasitol 2007;153:48-58] used the H+ ionophore nigericin, in conjunction with an acidic medium, to acidify the...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Molecular and Biochemical Parasitology
DOI: 10.1016/j.molbiopara.2008.07.001


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