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A flavivirus signal peptide balances the catalytic activity of two proteases and thereby facilitates virus morphogenesis

Lobigs, Mario; Lee, Eva; Ng, Mah Lee; Pavy, Megan; Lobigs, Paivi


Two cleavages on either side of a signal peptide separating capsid and prM on the nascent flavivirus polyprotein are uniquely regulated, such that cytosolic capsid cleavage triggers signalase cleavage of prM. Here, we show, using two experimental approaches, that this sequential order of cleavages facilitates virus morphogenesis: (i) A Murray Valley encephalitis virus (MVEV) variant, in which both cleavages occurred efficiently and independently of each other, displayed an assembly defect. (ii)...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Virology
DOI: 10.1016/j.virol.2010.02.008


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